42 articles - From Friday Jul 29 2022 to Friday Aug 05 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Clin J Am Soc Nephrol |
Acute Kidney Injury in Patients with Liver Disease. Direct-acting antivirals with or without immunosuppression are used to treat hepatitis B/C-associated GN. In summary, AKI in cirrhosis requires careful consideration of multiple potentially pathogenic factors and the implementation of targeted therapeutic interventions. |
Association of Genetically Predicted Fibroblast Growth Factor-23 with Heart Failure: A Mendelian Randomization Study. . Mendelian randomization leverages genetic determinants of a risk factor to examine causality. We performed a two-sample Mendelian randomization to assess causal associations between FGF23 and heart failure. Design, setting, participants, & measurements Genetic instruments were genome-wide significant genetic variants associated with FGF23, including variants near interaction = 2.25 |
Quality of Life before and after the Start of Dialysis in Older Patients. Patients experienced a clinically relevant decline of both mental and physical health-related quality of life before dialysis initiation, which stabilized thereafter. These results may help inform older patients with kidney failure who decided to start dialysis. |
Three Times Weekly Dosing of Daprodustat versus Conventional Epoetin for Treatment of Anemia in Hemodialysis Patients: ASCEND-TD: A Phase 3 Randomized, Double-Blind, Noninferiority Trial. In this noninferiority trial, we compared daprodustat administered three times weekly with epoetin alfa (epoetin) in patients on prevalent hemodialysis switching from a prior erythropoiesis-stimulating agent (ESA). Design, setting, participants, & measurements Patients on hemodialysis with a baseline hemoglobin of 8-11.5 g/dl receiving an ESA were randomized 2:1 to daprodustat three times weekly ( a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Three Times Weekly Dosing in Dialysis (ASCEND-TD), NCT03400033. |
| J Am Soc Nephrol |
Complementary Nck1/2 Signaling in Podocytes Controls a Actinin-4-Mediated Actin Organization, Adhesion, and Basement Membrane Composition. These findings reveal distinct, yet complementary, roles for Nck proteins in regulating podocyte adhesion, controlling GBM composition, and sustaining filtration barrier integrity. |
Early Molecular Events Mediating Loss of Aquaporin-2 during Ureteral Obstruction in Rat. Within 3 hours follows upregulation of immediate-early and inflammatory genes and disappearance of the V2 vasopressin receptor, resulting in loss of AQP2 (confirmed by lipopolysaccharide administration). The inflammatory response seen rapidly after UUO establishment may be relevant to UUO-induced polyuria as well as to the long-term development of fibrosis in UUO kidneys. |
Sex Differences in the Recognition, Monitoring, and Management of CKD in Health Care: An Observational Cohort Study. There were profound sex differences in the detection, recognition, monitoring, referrals, and management of CKD. The disparity was also observed in people at high risk and among those who had guideline-recommended indications. |
Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney. These findings reveal a critical role for YAP/TAZ in specific embryonic stromal cells and suggest that interaction with cofactors, such as SRF, influence the expression of cell type-specific target genes, thus driving stromal heterogeneity. Further, this work reveals functional roles for renal stroma heterogeneity in creating unique microenvironments that influence the differentiation and maintenance of the renal parenchyma. |
| Kidney Int |
Cellular communication network 2 (connective tissue growth factor) aggravates acute DNA damage and subsequent DNA damage response-senescence-fibrosis following kidney ischemia reperfusion injury. Thus, our observations indicate that inhibition of CCN2 can mitigate IRI-induced acute kidney injury, DNA damage, and the subsequent DDR-senescence-fibrosis sequence. Hence, targeting CCN2 might help to protect the kidney from transplantation associated post-IRI chronic kidney dysfunction. |
| Nephrol Dial Transplant |
Clinical application of microRNAs in glomerular diseases. MicroRNAs and other RNAi approaches have been successfully used in vitro and in vivo to selectively manipulate gene transcription, making them pivotal agents for basic science research and candidates for targeted therapeutics. This review will focus on miRs and their potential as biomarkers and novel therapeutics for glomerular disease. |
miRNA-23a modulates sodium-hydrogen exchanger 1 expression: studies in medullary thick ascending limb of salt induced hypertensive rats. i) NHE1, a protein involved in sodium reabsorption at mTAL level and blood pressure regulation, is upregulated in our model; ii) this is due to a down-regulation of miRNA-23a; iii) expression levels of this miRNA are influenced by high sodium intake in mTALs of rats. The downregulation of miRNA-23a in human affected by essential hypertension corroborate our data and point on the potential role of miRNA-23a in the regulation of mTAL function following high salt intake. |
Validation of two IgA nephropathy risk-prediction tools using a cohort with a long follow-up. We have externally validated two prediction tools for IgA nephropathy. The International IgAN Prediction Tool performed well, while the IgA Nephropathy Clinical Decision Support System has some limitations. |
Validity and reliability of Patient-Reported Outcomes Measurement Information System (PROMIS®) using Computerized Adaptive Testing (CAT) in patients with advanced chronic kidney disease. PROMIS CATs showed sufficient construct validity and test-retest reliability in patients with advanced CKD. PROMIS CATs required more items but showed better reliability than the SF-12. Future research is needed to investigate the feasibility of PROMIS CATs for routine nephrology care. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Clin J Am Soc Nephrol |
| J Am Soc Nephrol |
| Nat Rev Nephrol |
Activation and regulation of alloreactive T cell immunity in solid organ transplantation. However, the programmed differentiation of allograft-specific T cell responses is probably distinct from that of pathogen-elicited responses, owing to the dearth of pathogen-derived innate immune activation in the transplantation setting. Understanding the fundamental (and potentially unique) immunological pathways that lead to allograft rejection is therefore a prerequisite for the rational development of therapeutics that promote transplantation tolerance. |
| Nephrol Dial Transplant |
Letters to the editors and authors’ replies
| J Am Soc Nephrol |
all remaining publications eg case reports, images of the month, etc…
| Clin J Am Soc Nephrol |
| J Am Soc Nephrol |
| Nat Rev Nephrol |